Shelliver

Shelliver herbal distilled is a combination of 7 different medicinal plants: Cichorium intybus, Cynara scolymus, Echium amoenum, Fumaria officinalis, Silybum marianum, Taraxacum officinale and Viola odorata. All of them have therapeutic effects in improving the fatty liver (alcohol and non-alcoholic), controlling blood lipids, regulating liver enzymes, skin problems and controlling blood sugar. Shelliver has been produced by Parsiteb company.

The liver is one of the largest and most important parts of the human body, and the lack of treatment causes complicated liver diseases, cirrhosis and death. The prevalence of this disease worldwide is estimated to be 35% and in Asia it is estimated to be 30-50% in adolescents. Like most chronic liver diseases, most people with asymptomatic non-alcoholic fatty liver are often asymptomatic, and only after finding abnormal laboratory tests, or because of sonography for various reasons, such as gallstones, fatty liver disease, diagnosis given. So far no remedial treatment has been proposed for this disease and there is no proper and ideal treatment. Medicinal plants have always been considered as an alternative to industrial medicines due to ease of access, reduced side-effects and reasonable prices. So, one of the most effective herbal medicine to treat liver diseases is Shelliver.

Shelliver herbal distilled, is a combination of 7 medicinal plants. It is effective in treatment of liver problem.

Other usages of this product are following: To treat the diseases caused by abnormal yellow bile, liver weaknesses, skin problems, regulate liver enzymes, painful menstruation and Jaundice.

The invention with No. 92185 was registered on 13/06/2017. As a distilled of 7 medicinal plants (Shelliver) to treat liver problems. This product on 29.07.2017 with No. 21422 by the letter of the Department of Technology, Ferdowsi University of Mashhad, after scientific validation (with the feature of being new, being innovative, and the applicability of the mentioned items, in the field of technical knowledge and procurement method) is approved.

The usage of this product is 80-100 ml per day and 2 hours before lunch. The best time to use it at the height of thirst (the thirstier patient can absorb the product more). It should be noted that the duration of using Shelliver and achieve a complete result depends on the duration of the person's diseases, the presence or absence of other diseases, the age of the patient, the degree of observance and the extent of the disease. In general, for a moderate level of diseases, the period is one month. This product is not recommended for people with constipation.

Non-alcoholic fatty liver is one of the main causes of chronic liver disease in children and its prevalence in obese children has been reported from 42.6% to 77.1% in various studies. In the near future, the disease is expected to be the most common cause of chronic liver disease in children.

Shelliver herbal distilled is a combination of 7 different medicinal plants: Cichorium intybus, Cynara scolymus, Echium amoenum, Fumaria officinalis, Silybum marianum, Taraxacum officinale and Viola odorata. All of them have therapeutic effects in improving the fatty liver (alcohol and non-alcoholic), controlling blood lipids, regulating liver enzymes, skin problems and controlling blood sugar.

Each ml of Shelliver contains Anthocyanin, Cynarin, Fumaricine, Silymarin, Taraxalisin, Thiobarbituric acid and Violet (It should be noted that it is an ingredient of the essential oil of any plant that is effective in the treatment of liver disease).

Applications of this herbal distilled are following: To treat the diseases caused by abnormal yellow bile, liver weaknesses, skin problems, regulate liver enzymes, painful menstruation and Jaundice.

The invention with No. 92185 was registered on 13/06/2017. As a distilled of 7 medicinal plants (Shelliver) to treat liver problems.

This product on 29.07.2017 with No. 21422 by the letter of the Department of Technology, Ferdowsi University of Mashhad, after scientific validation (with the feature of being new, being innovative, and the applicability of the mentioned items, in the field of technical knowledge and procurement method) is approved.

The early stages of the clinical tests were conducted in a pilot experiment. For this purpose the product was used as a supplement in the diet of patients. So, repeatedly checked the positive effects of the product on patients with liver problems. The results have shown that in 80% of the people who were considered as clinical community, taking this diet disrupted the symptoms of the disease. The minimum performance of this product for other people has been to prevent the progression of liver problems.

The usage of this product is 80-100 ml per day and 2 hours before lunch. The best time to use it at the height of thirst (the thirstier patient can absorb the product more). It should be noted that the duration of using Shelliver and achieve a complete result depends on the duration of the person's diseases, the presence or absence of other diseases, the age of the patient, the degree of observance and the extent of the disease. In general, for a moderate level of diseases, the period is one month. This product is not recommended for people with constipation.

Pharmacological effects of Shelliver (7 medicinal plants)

Liver Diseases

One of the reasons for liver damage in biliary obstruction, is to increase bile acidity and change the oxidant balance of the antioxidant which can lead to multiple complications by stimulating lipid peroxidation. In addition, oxidative stress usually increases in cirrhosis (Kume, 2004; Oyedemi, 2011). Also Cichorium intybus and Silybum marianum contain large amounts of anthocyanins vitamins A and C that can reduce inflammation and cholestatic complications.

In addition, by reducing the activity of oxidizing agents (MDA) malondialdehyde and increaseing the activity of antioxidant agents like (SOD) dismutase superoxide and (GHS) Glutathione hepatic, shelliver can protect the liver against carbon tetrachloride fibrosis.

Polyphenolic compounds that present in shelliver can protect liver cells against damages of liver toxins and free radicals (Sakihama, 2002). This therapeutic properties are achieved through the stability of the cell membrane and preventing the oxidation of membrane lipids by active.

Also it can decrease liver toxicity by modifying hepatic enzymes such as serum aminotransferases SGOT, SGPT, Alkaline phosphatase and bilirubin.

Skin problems

A beneficial liver enhancer (Shelliver) is useful for restoring skin health as complications of fatty liver. Shelliver compounds play a significant role in facilitating and strengthening the liver and treating its diseases and eliminating the skin problems that caused by liver toxins. Also by applying the antioxidant mechanism and the elimination of toxins and zeros as well as the neutralization it provides cell regeneration and rejuvenation for the liver and prevents skin problems (Luper, 1999). Also by lowering gallbladder in blood, Skin complications such as psoriasis, hives and allergies as well as eczema and psoriasis are eliminated. These valuable and beneficial effects depend are on the effective ingredients including alkaloids, Prothyridine, Silymarin, Traxanthin, vitamin A, B and C. (Vogel, 1975).

In liver disease, biliary obstruction usually causes, deposition of fat and bile secretions, secreted into the bloodstream and their symptoms are in the form of liver spots, skin jaundice, itchy skin and brown spots. In this condition, the liver cannot absorb free radicals from the blood, thus the skin problems increase. One of the ways to reduce these radicals in the body is taking antioxidant-rich medications that prevents the cells from being destroyed. One of these herbal medicine is Shelliver. Based on all plants used in Shelliver with antioxidants effects it can produce bile eliminate toxins from the liver, reduce the destruction of the walls of the liver cells and purify blood.

Thromboxane (TXA3), Lecturers (LTBS) and prostaglandin in the Shelliver through the mechanism of increasing the secretion of bile acids and the reduction of stool natural stress can lead to improved skin problems. Shelliver compounds stimulate collagen production and shorten wound shrinkage (McDaniel, 2008), angiogenesis, vascular dilatation, decreased inflammation as well as skin problems.

Silymarin significantly reduces the number of interleukin-producing cells 10, as well as its production in the inflamed skin of ultraviolet radiation. It is also able to inhibit macrophage activating Lipopolysaccharides.

Silymarin is also traditionally used to treat psoriasis. The effect of silymarin for improvement of psoriasis due to the elimination of unwanted metabolites of body cells especially the liver as well as inhibition of the cycle cAMP and inhibiting the synthesis of Leukotrienes. It increases cycle cAMP time in patients with psoriasis and the synthesis of Leukotrienes whose containment is likely to result in a recovery of the disease (Koch, 1985).

Shelliver is a combination of lactobenic-containing compounds Doxy lactosine 8, a potent inhibitor of cyclooxygenase type two (Hassan, 2008), as well as some of the existing flavonoids and anthocyanins stimulating the immune system and limiting infection and inflammation (Anis,2001).

Treatment of jaundice

Abnormal increase in bilirubin concentration in the blood, which is due to a poor functioning of the liver creates a yellow color in the skin and eyes. Shelliver can reduce bilirubin and the levels of Malondialdehyde the liver is reduced and the levels of albumin, protein and levels of antioxidant liver enzymes increase, resulting in improved disease.

Blood glucose control

Insulin is an antitryptic hormone in the case of insulin resistance it interferes with various pathways in steatosis and lipid accumulation in the liver. In normal situation fatty acids have been transferred to the liver through the blood stream, there by one of the important liver cells called mitochondria which are the source of cellular energy production, changes in phospholipid are removed from the liver. This process is regulated by the effects of hormones and especially insulin. The accumulation of fat in the liver cells occurs when the production of fat is increased and their secretion from the liver is disturbed. This phenomenon occurs when the amount of fat in the liver is increased or due to dysfunction in mitochondria, the process of production and secretion of phospholipids is reduced. Insulin resistance is one of the most important factor. People with diabetes or obesity has insulin resistance which this increases the amount of fatty acids in the liver. The accumulation of these substances in the liver can be destructive and can lead to the death of the liver (Schmitz-Peiffer, 2000). By weakening the factors that lead to the excretion of fat from the liver cells (oxidation and fat fuel) and overcoming the factors that increase fat intake to the liver (Insulin resistance) the accumulation of fat inside the liver cells is caused.

Effective components of each medicinal plants used in Shelliver can affect the liver chemical intermediates including diponectin (an important factor in liver susceptibility to insulin) and increase its activity. On the other hand it also can decrease the activity of another mediator called TNFα , by preventing the entry of fatty acids into the liver cells, increased fat metabolism inside the liver cells, preventing the accumulation of fat in the liver and thereby reducing insulin resistance (Khan, 2003). Also, phenolic compounds and flavonoids can reduce the levels of aspartate transaminase enzymes (AST) (Kalailingam, 2011) and Alanine Trans-Amina Z (ALT) (Aydin, 2001). Revitalize the liver cells against glutathione emptying or by increasing the antioxidant enzymes of glutathione reductase Glutathione peroxidase and catalase. on the other hand these antioxidant compounds including flavonoids quercetin inhibit the absorption of glucose in the intestine (Loew, 2002) this action is done specifically on the GLUT2 vector (Singh, 2012) and Acetyl coenzyme A from pirovic acid instead of entering the triglyceride synthesis step it enters the krebs cycle (citric acid cycle), by lowering the blood glucose level and storing glucose to the glycogen. It ultimately leads to blood sugar control.

References

• Abascal K, Yamell E. The many faces of silybum marirnum (Milk Thistle): Part 1- Treating Cancer and Hyperlipidemia and Restoring Kidney Function. Alternat Complement Ther 2003; 9(4): 170-175.

• Anis, K. V., Rajeshkumar, N. V., & Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. Journal of Pharmacy and Pharmacology, 53(5), 763-768.

• Ghosh N, Ghosh R, Mandal V, Mandal SC. Recent advances in herbal medicine for treatment of liver diseases. Pharm Biol 2011; 49(9): 970-988.

• Kalailingam, P., Sekar, A. D., Samuel, J. S. C., Gandhirajan, P., Govindaraju, Y., Kesavan, M., & Tamilmani, E. (2011). The efficacy of Costus igneus rhizome on carbohydrate metabolic, hepatoproductive and antioxidative enzymes in streptozotocin-induced diabetic rats. Journal of Health Science, 57(1), 37-46.

• Khan, A., Safdar, M., Khan, M. M. A., Khattak, K. N., & Anderson, R. A. (2003). Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes care, 26(12), 3215-3218.

• Koch, H. P., Bachner, J., & Löffler, E. (1985). Silymarin: potent inhibitor of cyclic AMP phosphodiesterase. Methods and findings in experimental and clinical pharmacology, 7(8), 409-413.

• Kume, E., Fujimura, H., Matsuki, N., Ito, M., Aruga, C., Toriumi, W., & Doi, K. (2004). Hepatic changes in the acute phase of streptozotocin (SZ)-induced diabetes in mice. Experimental and Toxicologic Pathology, 55(6), 467-480.

• Luper, S. (1999). A review of plants used in the treatment of liver disease: part two. Alternative medicine review: a journal of clinical therapeutic, 4(3), 178-188.

• McDaniel, J. C., Belury, M., Ahijevych, K., & Blakely, W. (2008). Omega‐3 fatty acids effect on wound healing. Wound Repair and Regeneration, 16(3), 337-345.

• Oyedemi, S. O., Bradley, G., & Afolayan, A. J. (2011). Beneficial Effect of Aqueous Stem Bark Extracts of Strychnos henningsii Gilg in Streptozotocin-nicotinamide Induced Type 2 Diabetic Wistar Rats. International Journal of pharmacology, 7(7), 773-781.

• Sakihama, Y., Cohen, M. F., Grace, S. C., & Yamasaki, H. (2002). Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicology, 177(1), 67-80.

• Schmitz-Peiffer, C. (2000). Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. Cellular signalling, 12(9), 583-594.

• Singh, P. K., Baxi, D., Banerjee, S., & Ramachandran, A. V. (2012). Therapy with methanolic extract of Pterocarpus marsupium Roxb and Ocimum sanctum Linn reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model. Experimental and Toxicologic Pathology, 64(5), 441-448.

• Soto C, Recoba R, Barrón H, Alvarez C, Favari L. Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol C Toxicol Pharmacol 2003; 136(3): 205-212.

• Toit, R., Volsteedt, Y., & Apostolides, Z. (2001). Comparison of the antioxidant content of fruits, vegetables and teas measured as vitamin C equivalents. Toxicology, 166(1), 63-69.

• Vogel, G., Trost, W., Braatz, R., Odenthal, K. P., Brüsewitz, G., Antweiler, H., & Seeger, R. (1975). Pharmacodynamics, site and mechanism of action of silymarin, the antihepatoxic principle from Silybum mar.(L) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) pharmacology. Arzneimittel-Forschung, 25(1), 82.

The invention with No. 92185 was registered on 13/06/2017 as a distilled of 7 medicinal plants (Shelliver) to treat liver problems. This product on 29/07/2017 with No. 21422 by the letter of the Department of Technology, Ferdowsi University of Mashhad, after scientific validation (with the feature of being new, being innovative, and the applicability of the mentioned items, in the field of technical knowledge and procurement method) is approved.

Shelliver herbal distilled is a combination of 7 different medicinal plants: Cichorium intybus, Cynara scolymus, Echium amoenum, Fumaria officinalis, Silybum marianum, Taraxacum officinale and Viola odorata. All of them have therapeutic effects in improving the fatty liver (alcohol and non-alcoholic), controlling blood lipids, regulating liver enzymes, skin problems and controlling blood sugar. Shelliver has been produced by Parsiteb company.

Each ml of Shelliver contains Anthocyanin, Cynarin, Fumaricine, Silymarin, Taraxalisin, Thiobarbituric acid and Violet. (It should be noted that it is an ingredient of the essential oil of any plant that is effective in the treatment of liver disease).

Applications of this herbal distilled are following: To treat the diseases caused by abnormal yellow bile, liver weaknesses, skin problems, regulate liver enzymes, painful menstruation and Jaundice.

The early stages of the clinical tests were conducted in a pilot experiment. For this purpose the product was used as a supplement in the diet of patients. So, repeatedly checked the positive effects of the product on patients with liver problems. The results have shown that in 80% of the people who were considered as clinical community, taking this diet disrupted the symptoms of the disease. The minimum performance of this product for other people has been to prevent the progression of liver problems.

The usage of this product is 80-100 ml per day and 2 hours before lunch. The best time to use it at the height of thirst (the thirstier patient can absorb the product more). It should be noted that the duration of using Shelliver and achieve a complete result depends on the duration of the person's diseases, the presence or absence of other diseases, the age of the patient, the degree of observance and the extent of the disease. In general, for a moderate level of diseases, the period is one month. This product is not recommended for people with constipation.