About 10 to 45 percent of people through their lives are suffer from digestive disorders, especially dyspepsia. The prevalence of this disease has been reported in the Iranian population between 8.5% and 29%. About 2 to 7 percent of the visits of a general practitioner are patients with indigestion. This represents about 25% of the population with indigestion. In every 100,000 people between the ages of 25 and 44, about 355 people with indigestion refer to general practitioners and households. So, it increases due to the ages.
Parsiteb 5 herbal distilled is a combination of 5 different medicinal plants: Foeniculum vulgare, Cuminum cyminum, Trachyspermum copticum, Teucrium polium and Elettaria cardamomum. All of them have therapeutic properties to treat digestive problem. Parsiteb 5 has been produced by Parsiteb Company.
Each ml of Parsiteb 5 contains Thymol, Limonene, 1,8- Cineole, Beta-Sitosterol and anthoole (It should be noted that this component is an essential component of these plant that is effective in the treatment of digestive diseases).
Applications of this herbal distilled are following:
Dyspnea treatment, decongestant and diarrhea, treatment of cramps and diarrhea, pulmonary Strengthening, bladder strengthening and adjustment of the immune system.
The early stages of the clinical tests were conducted in a pilot experiment. For this purpose the product was used as a supplement in the diet of patients. So, repeatedly checked the positive effects of the product on patients with digestive problems. The results have shown that in 80% of the people who were considered as clinical community, taking this diet disrupted the symptoms of the disease. The minimum performance of this product for other people has been to prevent the progression of digestive disease.
The usage of this product is 80-100 ml per day and 2 hours before lunch. The best time to use it at the height of thirst (the thirstier patient can absorb the product more).
It should be noted that the duration of using Parsiteb 5 and achieve a complete result depends on the duration of the person's diseases, the presence or absence of other diseases, the age of the patient, the degree of observance and the extent of the disease. In general, for a moderate level of diseases, the period is one month. This product is not recommended for people with constipation.
Pharmacological effects of Parsiteb 5
Treat the Gastrointestinal Problems
Dehydration of fennel due to having antol like dopamine can reduce or stop gastrointestinal spasms and increase gastric secretion and, consequently, increase digestibility. The collection of these acts can help eliminate indigestion. Also, the effective ingredients of this suppository prevent acetylcholine and histamine from intestinal spasm.
Fennel prevents intestinal fermentation and thus prevents the formation of gasses in the intestine. On the other hand, the active ingredients of this plant facilitate digestion. Fennel contains vegetable estrogen. Estrogens form a group of female sex hormones that "stratiol" is one of them. Estrogens are found in both males and females, but their levels are much higher in females, and in addition to their role in reproduction (both male and female), their role in the development of central nervous system (CNS), growth Bone and cardiovascular system is also very significant.
Essences present in this product, with local effect on the mucous membrane of the stomach wall, rapidly increase the activity of the nerve of the vagus and thereby increase the intensity of gastric motility, which results in exhaust gases from bloating and increased digestive system secretions and causes bloating. As well as accelerating the digestion of food and preventing the fermentation of food and the production of gas.
Considering that thymol is the most common substance in the plant. The presence of this plant in Parsiteb 5 through its effect on serotonergic, cholinergic, gobarergic and 2-α-adrenergic systems can be effective in reducing the symptoms of digestive problems (Miri et al., 2005).
Benzoflavonoid in this product, which has an effect on one of the GABA receptors, causes synaptic inhibition and significantly reduces the activity of the central nervous system in relieving pain and anxiety and improving digestive disorders (Umezu et al., 2008).
Among other effective mechanisms for inhibiting the symptoms of gastrointestinal discomfort with this product, inhibiting the binding of calcium to the voltage-dependent calcium channel in the pre-synaptic membrane, or directly affecting the digestive nerves that induces the antispasmodic effects of this product.
Thymol in fennel with an effect on kappa opioid receptors and inhibiting the transmission of pain signals reduces pain and has an antispasmodic effect (Vafaei et al., 2011). This product is rich in potassium and contains flavonoids and pectin. These compounds relax the muscles and reduce diarrhea (Miladi Gorji et al., 2007).
Possibly, the Teucrium polium with anti-dopaminergic and anticholinergic activity reduces the symptoms of digestive ailments. The anti-cream effect of this product is due to the presence of thymus and its anti-spasmodic and antispasmodic properties relate to its essential oil (Nadkarinis, 1976). Fennel extract presented in this product can reduce the passage of food, as well as increase the activity of digestive enzymes and also increase the secretion of bile acids (Platel et al., 2001). On the other hand, it increases local gastrointestinal movements and thereby helps intestinal excretion (Jabbar et al., 2006).
The compounds present in this product can protect against gastric ulcers by neutralizing free radicals, which is one of the mechanisms of the development of ulcers. In gastric mucosa, antihistamine compounds inhibit the secretion of gastric acid, which can contribute to gastric secretion against ulcers. Given that antihistaminic activity has been reported for cumin. It can use as a protective protein and prevents the action of histamine receptors. So, it cause one can use one of the protective cucumber proteins used in this product in a way that prevents the action of histamine receptors. It causes excessive acid secretion in the gastric wall (Boskabady et al., 2000). Ethanol leads to the destruction of cells and the formation of mucosal lesions. In contrast, the anti-scrotum effect of herbal extracts and essential oils is based on anti-secretion action or protective function of the cells.
The therapeutic compounds presented in this product have a major activity against stomach ulcers (Hiruma-Lima et al., 2001). Flavonoids present in this product have protective effects on the mucus of the stomach. As these compounds, while having anti-oxidant effects, help remove wound healing by removing free radicals. On the other hand, lipolysis inhibition prevents mucosal agent from penetrating the necrosis factor. The flavonoids and sterols presented in tuberculosis are the main cause of the anti-inflammatory activity of this product. Sharifian et al. (2004)
The extracts used in this product due to the presence of phenolic compounds and antioxidant properties caused by the presence of these compounds leads to the inactivation of free radicals produced and prevents damage to cell membranes and causes digestive problems. Also, green peppermint extract with compounds such as fiber (Larsen, 1996) and also due to the presence of flavonoids with inhibiting free radicals (Hitoshi et al., 2005) may improve gastrointestinal function.
On the other hand, there is a complex of Cineol 5 on the cardboard pin. Cineol plants are useful for gastrointestinal disorders (Aggarwal, 2009). The effect of anti-nausea is due to its local effects on the gastrointestinal wall (Parthasarathy, 2008). In most studies, cardamom has gastrointestinal protective properties (Shekar Kumar et al., 2007).
Reducing stress in digestive problems
Parsiteb 5 has flavonoids that have a sedative effect. It is likely that the flavonoids contained in HPA (Hypothalamic-Pituitary-Adrenal), and this is activated in stress and anxiety (Butterweck et al., 2007).
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