Dry skin is a very common skin condition characterized by a lack of the appropriate amount of water in the most superficial layer of the skin, the epidermis. While dry skin tends to affect males and females equally, older individuals are typically much more prone to dry skin. The skin in elderly individuals tends to have diminished amounts of natural skin oils and lubricants.
Ato Restoration Herbal Cream is a combination of 3 different medicinal plants (Aloe vera, Olea europaea and Ricinus communis), which have therapeutic effects to reduce inflammation and itching the skin and also regenerate and repair the skin. Ato Restoration Herbal Cream has been produced by Parsiteb Company. Each mg of Ato Restoration Herbal Cream contains Aloin, Oleuropein and Tetramethrin (It should be noted that these components are essential components of these plants that are effective to treat dry skins).
Applications of this herbal cream are following: Deterioration of the skin treatment, skin moisturizer, treating dryness skins, restoration and nutrition of the skin and proper for sensitive skins.
The early stages of the clinical tests were conducted in a pilot experiment. For this purpose the product was used as a supplement in the diet of patients. So, repeatedly checked the positive effects of the product on patients with dry skin problems. The results have shown that in more than 90% of the people who were considered as clinical community, using this cream disrupted the symptoms of the disease. The minimum performance of this product for other people has been to prevent the progression of skin dryness problems.
After washing and cleansing the skin, while the skin is still moisture, massage it on the skin slowly. To get a complete result, leave it on the skin during a night. Used this product 3-5 nights per week until you can see the result.
Note 1. Patients with dry skin should avoid to use chemical soaps and body shampoos or unbalanced pH soaps, soil, chemical materials such as chemical colors and building materials.
Note 2. Castor oil and olive oil used in this cream do not block the pores of the skin and allow the skin to breathe normally.
Pharmacological effects of Ato Restoration Herbal Cream
Skin dryness treatment
The cause of dry skin is the lack of water in the horny layer of the skin, which leads to reduced skin flexion and it causes scaling, itching and dryness of the skin (Casetti et al., 2011). Herbal oils contain nutrients, vitamins, fatty acids and salts. Each of them can be part a of the skin's requirement. These acids help to keep the skin moisture and prevent skin dryness (Kapor et al., 2009). Also, the olive oil and castor oil in the Ato cream easily penetrates to the layers of the skin and then can absorb water and maintain it for a long time (Li et al., 2001).
Ato herbal moisturizing complex also promotes in the skin rapidly by adjusting the osmotic balance of the skin. Linoleic acid, one of the ingredients in this cream, with a natural moisturizing effect, can maintain the balance of the skin's fat and increase its elasticity. Castor oil is rich in flavonoids, Beta-carotene, and vitamins C and E. The linoleic acid found in this cream is essential for skin regeneration. To a large extent, it makes the skin soft (Glaser et al., 2003).
Salicylic acid in the cream, with its keratolytic properties, can peel dead skin cells and cleaning the skin (Schante et al., 2012). The Hyaluronic acid present in this cream is one of the natural components of human skin that has a high tendency to bind to water molecules and plays an important role to keep the skin moisture (Schante et al., 2011).
The ingredients in the Ato cream, due to the fact that they are attached to the affected skin, produce a false scar. It affect the repair of keratinocytes and improve the damaged skin. Repairing of damaged skin is due to the presence of a compound called glucomannan, which affects the growth of the skin cells and provides a healing effect. Glucomannan in Aloe Vera produces collagen, and collagen can repair the skin by increasing the elasticity of it (Joseph et al., 2010). The compounds in this cream increase the blood vessels, proliferate fibroblasts and create moisture that treat skin damages.
Aloe Vera present in Ato cream, can heal and reduce the inflammation of the skin by inhibiting thromboxane (Bosley et al., 2003). Also, Oleuropine in olive oil exacerbates the activity of the immune system and synthesizes Cytokines, which have anti-inflammatory effects on the skin. On the other hand, due to the effect of this substance on gram negative and positive bacteria and antiviral effects, it can treat skin inflammation.
Flavonoids in this cream such as epinephrine, with inhibiting phospholipase A2, prevent the release of Arachidonic Ad from the cell membrane and block the pathway of cyclooxygenase and lipoxygenase. It leads to the inhibition of the inflammatory mediator’s synthesis such as prostaglandins and leukotrienes. Antioxidants in the Ato cream, prevent the release of radicals. It helps to rebuild skin cells (Bozi et al., 2007).
By inhibiting the oxidative stress response and reducing the expression of the genes of inflammatory cytokines such as interleukin 1 and 6, contribute to their anti-inflammatory properties, the compounds in castor oil have a positive effect to treat skin inflammation. On the other hand, the anti-inflammatory properties of the Ato cream can be attributed to the alkaloids contained therein. This compound eliminates skin inflammation by reducing nitric oxide and cytokinins (Coca et al., 2016).
The compounds in the cream prevent the histamine reaction, which causes itching and skin irritation. Antioxidant, anti-inflammatory, anti-microbial and anti-carcinogenic effects of the compounds in Ato cream, reduce itching of the skin (Talal et al., 2003). Coumarin, saponin and flavonoid in the medicinal plants used in Ato cream have anti-viral and anti-fungal properties, so it reduce skin itching. Also, Aloe Vera contains 6 antiseptic compounds including lupoil, salicylic acid, urea, cinnamonic acid, phenol and sulfur, which has an inhibitory effect on the activity of fungi, bacteria and even viruses.
To treat psoriasis problems
As mentioned, the medicinal plants used in this cream with several therapeutic approaches, can treat dryness, scaling and thickness of the skin causes of psoriasis. One of these approaches is moisturizing the skin, which is due to the Aloe Vera properties found in this cream (Menter et al., 2008). Also, by reducing the proliferation of skin cells, Ato herbal cream improves the symptoms of psoriasis on the skin (Michaelsson et al., 2000). Castor oil and olive oil used in this cream can reduce inflammation which can help to improve psoriasis.
The other ingredients in this cream are alkaline phosphatase and the metalloproteinase matrix, which play important role in the metabolism of the skin cells. According to the fungal diseases exacerbate the skin problems of psoriasis, these compounds with antimicrobial and antifungal properties can treat the symptoms of psoriasis problems (Kovács et al., 2015). For example, vitamin A in this complex regulates the proliferation of skin epidermis cells and prevents the accumulation of keratin and lamina (Babina et al., 2017).
Vitamin E in this complex also has antioxidant properties and prevents oxidation of unsaturated fatty acids (Thiele et al., 2005). Vitamin D also plays a role in regulating the proliferation and differentiation of keratinocytes (Mattozzi et al., 2016).
On the other hand, the herbal compounds present in the Ato cream have an inhibitory effect on the pre-inflammatory cytokines such as TNFα and intercolines 6, 2.1, 12.8, indirectly inhibit the intercellular axis of 23-17 and decrease the proliferation of keratinocytes. Therefore, Ato herbal cream can be effective in the treatment of skin problems such as psoriasis.
- Aburjai, Talal, and Feda M. Natsheh. "Plants used in cosmetics." Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 17, no. 9 (2003): 987-1000
- Babina, Magda, Metin Artuc, Sven Guhl, and Torsten Zuberbier. "Retinoic acid negatively impacts proliferation and MCTC specific attributes of human skin derived mast cells, but reinforces allergic stimulability." International journal of molecular sciences 18, no. 3 (2017): 525.
- Bosley, C., J. Smith, P. Baratti, D. L. Pritchard, X. Xiong, C. Li, and T. E. Merchant. "A phase III trial comparing an anionic phospholipid-based (APP) cream and aloe vera-based gel in the prevention and treatment of radiation dermatitis." International Journal of Radiation Oncology• Biology• Physics57, no. 2 (2003): S438.
- Bozzi, A., C. Perrin, S. Austin, and F. Arce Vera. "Quality and authenticity of commercial aloe vera gel powders." Food chemistry 103, no. 1 (2007): 22-30.
- Casetti, F., U. Wölfle, W. Gehring, and C. M. Schempp. "Dermocosmetics for dry skin: a new role for botanical extracts." Skin pharmacology and physiology 24, no. 6 (2011): 289-293.
- Coca, Kelly Pereira, Karla Oliveira Marcacine, Mônica Antar Gamba, Luciana Corrêa, Ana Cecília Corrêa Aranha, and Ana Cristina Freitas de Vilhena Abrão. "Efficacy of low-level laser therapy in relieving nipple pain in breastfeeding women: a triple-blind, randomized, controlled trial." Pain Management Nursing 17, no. 4 (2016): 281-289.
- Eshun, Kojo, and Qian He. "Aloe Vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries—a review." Critical reviews in food science and nutrition 44, no. 2 (2004): 91-96. Glaser, Dee Anna. "Anti-aging products and cosmeceuticals." Facial plastic surgery clinics of North America 12, no. 3 (2004): 363-72.
- Joseph, Baby, and S. Justin Raj. "Pharmacognostic and phytochemical properties of Aloe Vera an overview." International journal of pharmaceutical sciences review and research 4, no. 2 (2010): 106-110.
- Kapoor, Shweta, and Swarnlata Saraf. "Efficacy study of sunscreens containing various herbs for protecting skin from UVA and UVB sunrays." Pharmacognosy Magazine 5, no. 19 (2009): 238.
- Kovács, Sandra, M. R. Wilkens, and A. Liesegang. "Influence of UVB exposure on the vitamin D status and calcium homoeostasis of growing sheep and goats." Journal of animal physiology and animal nutrition 99 (2015): 1-12.
- Li, Fang, Eileen Conroy, Marty Visscher, and R. Randall Wickett. "The ability of electrical measurements to predict skin moisturization. II. Correlation between one-hour measurements and long-term results." Journal of cosmetic science 52, no. 1 (2001): 23-33.
- Mattozzi, Carlo, Giovanni Paolino, Antonio Giovanni Richetta, and Stefano Calvieri. "Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: an update." The Journal of dermatology 43, no. 5 (2016): 507-514.
- Menter, Alan, Alice Gottlieb, Steven R. Feldman, Abby S. Van Voorhees, Craig L. Leonardi, Kenneth B. Gordon, Mark Lebwohl et al. "Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics." Journal of the American Academy of Dermatology 58, no. 5 (2008): 826-850.
- Michaëlsson, Gerd, B. Gerden, Eva Hagforsen, Bo Nilsson, Inger Pihl‐Lundin, W. Kraaz, G. Hjelmquist, and L. Lööf. "Psoriasis patients with antibodies to gliadin can be improved by a gluten‐free diet." British Journal of Dermatology 142, no. 1 (2000): 44-51.
- Papakonstantinou, Eleni, Michael Roth, and George Karakiulakis. "Hyaluronic acid: A key molecule in skin aging." Dermato-endocrinology 4, no. 3 (2012): 253-258.
- Thiele, Jens J., Sherry N. Hsieh, and Swarna Ekanayake‐Mudiyanselage. "Vitamin E: critical review of its current use in cosmetic and clinical dermatology." Dermatologic surgery 31 (2005): 805-813.